About Our Lab

The Tanner Lab applies innovative physical chemistry toolkits to address cutting-edge challenges in biomedical and bioengineering research. Our work focuses on leveraging the unique properties of ionic liquids and nanomaterials to pioneer advancements in these fields. Curious about our ongoing projects or potential opportunities to contribute? Visit the Research tab for detailed insights into our groundbreaking work, and don’t hesitate to reach out if you’re interested in becoming part of our dynamic team!

Where Chemistry Powers Bioengineering

At the Tanner Lab, we tackle cutting-edge bioengineering challenges through a chemistry-driven approach. By deciphering the molecular interactions within drug delivery systems, we develop predictive frameworks and engineer task-specific solvents to revolutionize therapeutic delivery.

Below, a fluorescent cross-section of porcine skin showcases FITC-insulin penetration, facilitated by an ionic liquid (1:2 CAGE), highlighting our work in enhancing transdermal drug transport.

Porcine Skin

Projects

Ionic Liquids: Versatile, Tunable, and Bioengineered

Ionic liquids, composed of a bulky, asymmetric cation and an anion, have garnered widespread interest across diverse fields, including catalysis and energy applications. Their unique properties—non-volatility, recyclability, and molecular tunability—allow precise control over their physicochemical characteristics by modifying their ionic components. A selection of common cations and anions is depicted in the image below

By synthesizing biocompatible ionic liquids, we unlock their potential in biological applications. Structural modifications of the ionic components enable fine-tuning of their interactions with bio-interfaces, biomolecules, and pharmaceuticals, paving the way for tailored solutions to critical challenges in drug delivery, biomaterials, and therapeutic design.

Nanomaterials in Drug Delivery

Nanoparticles are widely regarded as ideal drug delivery systems, offering enhanced efficacy, safety, and specificity compared to traditional therapeutics. Their advantages are particularly evident in chemotherapy, where they aim to improve the targeted delivery of drugs like doxorubicin for cancer treatment.

However, despite their promise, most nanoparticle technologies fail to achieve clinical translation. Significant challenges—including biological barriers and clearance mechanisms—limit their effectiveness, with less than 5% of administered nanoparticles successfully reaching their intended target. Overcoming these hurdles remains a critical focus in advancing nanomedicine toward real-world therapeutic applications.

AgNP

Enhancing Nanomaterial Transport Through Transdermal Delivery

Nanomaterials are typically too large to penetrate the stratum corneum, limiting their ability to reach the epidermis and dermis. Can ionic liquids serve as carriers to transport nanoparticles through intact skin? This project explores the potential of ionic liquids to enhance transdermal nanomaterial delivery through a multidisciplinary approach involving:

Synthesis of ionic liquids and nanoparticles.
Ex vivo testing using porcine skin models
In vivo evaluation in murine models

Led by Alysha Hunter, this research aims to unlock new possibilities for transdermal drug delivery and nanomedicine applications.

Skin Schematic

Ioinc Liquids and Nanoparticles-facilitated Intravenous Delivery.

The efficacy of injected nanoparticles is severely limited, with only a small fraction reaching their intended target. Can we engineer ionic liquids to improve intravenous nanoparticle delivery and enhance therapeutic outcomes?

This project integrates:

Synthesis of ionic liquids, nanoparticles, and active compounds
In vitro evaluation
In vivo studies in murine models

Led by Christine Hamadani and supported by the PhRMA Foundation, this research aims to overcome current barriers in nanomedicine and targeted drug delivery.

Project2

Intracellular Drug Delivery with Ionic Liquid-Loaded Nanoparticles

Efficiently delivering drugs inside cells remains a major hurdle in cancer therapy. Can ionic liquids encapsulated within nanoparticles improve intracellular transport of chemotherapies, enhancing their therapeutic efficacy?

This project focuses on:

Synthesis of ionic liquids, nanoparticles, and active compounds
In vitro studies using cell culture models
In vivo evaluation in murine models

Led by Gaya Dasanayake, this research aims to develop next-generation drug delivery systems for more effective cancer treatments.

Project3