Sushil Mishra
Assistant Professor, Department of Biomedical Engineering
I use molecular dynamics simulations to uncover how glycosyltransferases (GnTs) recognize glycan substrates and coordinate catalytic motions. By connecting enzyme conformational dynamics to reaction kinetics, I quantify determinants of catalytic activity and substrate specificity.
Contact
Office Location
A306 Brevard Hall
The University of Mississippi
University, MS
Email
sushil@olemiss.edu
Phone
662-915-2623
Research Interests
I design and engineer glycan-binding proteins (lectins, scFv antibodies, peptides) using diffusion-based models to selectively recognize glycan biomarkers. We apply molecular dynamics simulations and experimental approaches to predict/measure binding interactions.
I use molecular dynamics simulations to uncover how glycosyltransferases (GnTs) recognize glycan substrates and coordinate catalytic motions. By connecting enzyme conformational dynamics to reaction kinetics, I quantify determinants of catalytic activity and substrate specificity.
I use molecular dynamics simulations to uncover how glycosyltransferases (GnTs) recognize glycan substrates and coordinate catalytic motions. By connecting enzyme conformational dynamics to reaction kinetics, I quantify determinants of catalytic activity and substrate specificity.
I use molecular dynamics simulations to uncover how glycosyltransferases (GnTs) recognize glycan substrates and coordinate catalytic motions. By connecting enzyme conformational dynamics to reaction kinetics, I quantify determinants of catalytic activity and substrate specificity.
